In a new study including Yale Cancer Center and Smilow Cancer Hospital researchers, the cancer immunotherapy drug pembrolizumab (Keytruda), increased survival for patients with advanced non-small cell lung cancer (NSCLC), a disease once considered an aggressive, and uniformly fatal cancer. "Five years ago, no one with this advanced cancer would have survived. Keytruda can cause side effects in many different parts of your body. No new treatment-associated safety concerns were identified, and a lower proportion of Keytruda-treated patients (31.2%) reported severe to life-threatening or fatal adverse events, compared with those receiving chemotherapy (53.3%). Immunotherapy drugs work by increasing the patient’s own immune response. Neither your address nor the recipient's address will be used for any other purpose. The drug had already been approved for lung, head and neck, bladder, skin cancers and Hodgkin lymphoma. How does SARS-CoV-2 get in your head and destroy your sense of smell. For nearly five decades, doctors have used various forms of immunotherapy to treat certain cancers. First-line treatment with Keytruda (pembrolizumab) continues to promote significant survival benefits and durable responses in people with metastatic non-small cell lung cancer (NSCLC) and high levels of PD-L1, compared with standard chemotherapy, according to five-year data from the KEYNOTE-024 Phase 3 clinical trial. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. I cant tell what will happen with your uncle. and Terms of Use. 1 year in, keytruda treatments. Keytruda was being tested for the first time in 305 lung cancer patients who had not been treated at all yet. Lung cancer experts are exploring combination regimens after single-agent Keytruda (pembrolizumab) gained approval for both the first- and second-line setting for patients with non-small cell lung cancer (NSCLC). A total of 305 participants were randomly assigned to receive either 200 mg of Keytruda every three weeks (154 patients) or an investigator’s choice of standard chemotherapy (151 patients). “Before 2014, the five-year survival rate for patients in the U.S. with advanced non-small cell lung cancer was only 5%,” Martin Reck, MD, PhD, of the German Center of Lung Research and Lung Clinic Grosshansdorf, in Germany, said in a press release. “We are grateful to the many patients and health care providers in this trial and our other trials for their essential role in these studies and in advancing cancer care,” Baynes said. Apart from any fair dealing for the purpose of private study or research, no Keytruda-treated patients also lived twice as long (26.3 months vs. 13.4 months) and a median of two months longer without disease progression (7.7 vs. 5.5 months), compared with those on chemo. Chemotherapy. In addition, combinations of immunotherapy drugs are being evaluated in clinical trials, and early results are very encouraging. This suggested that completing two years of this therapy provided a long-term survival benefit. This document is subject to copyright. or, by Yale University. Different types of cancers work better than others with Keytruda but it is showing a lot of promise and research is extremely strong for lung cancer. KEYTRUDA is indicated in New Zealand as an immunotherapy for the treatment of melanoma, non-small cell lung cancer (NSCLC), classical Hodgkin lymphoma, urothelial carcinoma, head and neck squamous cell carcinoma, microsatellite instability-high/mismatch repair deficient (MSI-H/dMMR) cancer and renal cell carcinoma. Then, in 2016, the FDA expanded its approval to allow the drug to be used as first-line therapy in patients with high PD-L1 expression. 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